Non-Cytochrome Redox Enzymes

• Other enzymes are responsible for oxidation and reduction of some drugs.
• Some have genetic polymorphism and some are subject to inhibition or induction.
• The following lists are not exhaustive.

  Enzyme	Example substrate
  Alcohol & aldehyde dehydrogenases	ethanol
  Monoamine oxidase (MAO)	dopamine
  Xanthine oxidase (XO)	allopurinol*

  * prodrug - metabolised to active drug (oxipurinol) by XO

Topic Code: 93354

must be prescribed or recommended by a consultant.