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Infected Ulcers (e.g. diabetic, vascular, pressure)

Pathogens

Drug Treatment

Empiric

Mild to moderate infection

amoxicillin+clavulanic acid

HMLSchedNZFPMLnoids

IV 1 g/200 mg every eight hours then PO 500 mg/125 mg three times a day

Mild penicillin allergy

cefuroxime

HMLSchedNZFPMLnoids

IV 1.5 g every eight hours

AND

metronidazole

HMLSchedNZFPMLnoids

PO 600 mg twice a day

followed by

cefalexin

HMLSchedNZFPML

PO 500 mg four times a day

AND

metronidazole

HMLSchedNZFPMLnoids

PO 600 mg twice a day

Severe penicillin allergy

ciprofloxacin

HMLSchedNZFPMLnoids

PO 500 mg twice a day

AND

clindamycin

HMLSchedNZFPMLnoids

PO 450 mg three times a day

Severe infection

piperacillin+tazobactam

HMLNZFPMLnoids

IV 4 g/500 mg every eight hours

Mild penicillin allergy

meropenem

HMLNZFPMLnoids

IV 1 g every eight hours

Severe penicillin allergy

Consult Infectious Diseases/Clinical Microbiology

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Topic Code: 99261