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Urinary Tract Infection / Pyelonephritis (Post-operative)

Urosepsis

Review culture and susceptibility results as soon as available, aiming to change to directed therapy on day 2. Do not use nitrofurantoin even if proven susceptibility in the laboratory as concentrations are too low to treat an infection outside of the bladder.

CrCl ≥ 20 mL/min

gentamicin

HMLSchedNZFPMLnoids

IV 5 mg/kg ideal body weight once daily (every 24 hours). Round dose down to nearest half vial (40 mg).

AND

amoxicillin

HMLSchedNZFPMLnoids

IV 2 g every eight hours

Penicillin allergy

gentamicin

HMLSchedNZFPMLnoids

IV 5 mg/kg ideal body weight once daily (every 24 hours). Round dose down to nearest half vial (40 mg).

AND

vancomycin

HMLSchedNZFPMLnoids

See dosing guidelines.

Renal failure (CrCl < 20 mL/min)

ceftriaxone

HMLSchedNZFPMLnoids

IV 2 g once daily (every 24 hours)

Previous infection with an extended spectrum beta-lactamase (ESBL)-producing organism

meropenem

HMLNZFPMLnoids

IV 1 g every eight hours

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Topic Code: 99287