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Sepsis (Post-operative)

Post-abdominal surgery

cefuroxime

HMLSchedNZFPMLnoids

IV 1.5 g every eight hours

AND

gentamicin

HMLSchedNZFPMLnoids

IV 5 to 7 mg/kg ideal body weight initially, then see dosing guidelines.

AND

metronidazole

HMLSchedNZFPMLnoids

IV 500 mg every twelve hours

Severe penicillin allergy – consult with Infectious Diseases/Clinical Microbiology

If multi-drug resistant organism isolated or suspected give

piperacillin+tazobactam

HMLNZFPMLnoids

(Tazocin™)

IV 4 g/500 mg every six hours

OR

meropenem

HMLNZFPMLnoids

IV 1 g every eight hours

Post-orthopaedic surgery

flucloxacillin

HMLSchedNZFPMLnoids

IV 2 g every six hours

PLUS

gentamicin

HMLSchedNZFPMLnoids

IV 5 to 7 mg/kg ideal body weight initially. See dosing guidelines

Mild penicillin allergy

cefazolin

HMLSchedNZFPMLnoids

IV 2 g every eight hours

PLUS

gentamicin

HMLSchedNZFPMLnoids

IV 5 to 7 mg/kg ideal body weight initially, then see dosing guidelines.

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Topic Code: 99283