Non-Gonococcal Urethritis

• Refer to Sexual Health for contact tracing and treatment of partners.

Pathogens

• Common: Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis
• Other: Herpes simplex, Ureaplasma urealyticum, other viruses, various skin bacteria

Drug Treatment

• Duration: See below.

Empiric

azithromycin HMLSchedNZFPML Azithromycin F: 0.4 Half life: 60 hours Elimination: substantial biliary excretion fe: 0.1 Additional points: ↑ warfarin effect.

PO 1000 mg stat

Pathogens Known

Chlamydia trachomatis

H. simplex

• fe (aciclovir – active metabolite) = 0.8, consider adjusting dose if reduced GFR.

OR

aciclovir HMLSchedNZFPMLnoids Aciclovir F: 0.2 Half life: 3 hours Elimination: renal fe: 0.8

PO 400 mg three times a day for 5 days

• fe = 0.8, consider adjusting dose if CrCl is reduced.

Mycoplasma genitalium

Refer to Sexual Health for advice on treatment.

Trichomonas vaginalis

See Trichomoniasis.

Topic Code: 99255

must be prescribed or recommended by a consultant.