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Diarrhoea – Clostridium difficile

Drug Treatment

Mild

Moderate

metronidazole

HMLSchedNZFPMLnoids

PO 400 mg three times a day

If metronidazole fails

vancomycin

HMLSchedNZFPMLnoids

PO 125 mg four times a day (use IV formulation orally or pharmacy can compound a liquid)

Severe

vancomycin

HMLSchedNZFPMLnoids

PO 500 mg four times a day (use IV formulation orally or pharmacy can compound a liquid)

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Topic Code: 99234