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Diarrhoea – Clostridioides difficile

Drug Treatment

Initial episode

Mild

Moderate

metronidazole

HMLSchedNZFPMLnoids

PO 400 mg three times a day

If metronidazole fails

vancomycin

HMLSchedNZFPMLnoids

PO 125 mg four times a day (use IV formulation orally or pharmacy can compound a liquid)

Severe

vancomycin

HMLSchedNZFPMLnoids

PO 125 mg four times a day (use IV formulation orally or pharmacy can compound a liquid)

Recurrence

vancomycin

HMLSchedNZFPMLnoids

PO 125 mg four times a day for 2 weeks, then 125 mg twice daily for 1 week, then 125 mg once daily for 1 week, then 125 mg every second day for 1 week, then 125 mg every three days for 1 week (use IV formulation orally or pharmacy can compound a liquid)

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Topic Code: 99234