Empiric treatment of aspiration pneumonia is divided into hospital-acquired and community-acquired disease.
amoxicillin+clavulanic acid |
PO 500 mg/125 mg three times a day (or IV 1 g/200 mg every eight hours) |
Mild penicillin allergy
cefuroxime |
PO 500 mg twice a day (or IV 1.5 g every eight hours) |
Severe penicillin allergy
clindamycin |
PO 450 mg three times a day (or IV 600 mg every eight hours) |
AND EITHER
gentamicin |
OR
ciprofloxacin |
PO 500 mg twice a day |
piperacillin+tazobactam |
IV 4 g/500 mg every eight hours |
Mild penicillin allergy
meropenem |
IV 1 g every eight hours |
Severe penicillin allergy
Consult Infectious Diseases/Clinical Microbiology/Respiratory Medicine.
amoxicillin |
PO 1000 mg three times a day (or IV 1 g every eight hours) |
Penicillin allergy
clindamycin |
PO 450 mg three times a day (or IV 600 mg every eight hours) |
ceftriaxone |
IV 1 g every 24 hours |
AND
metronidazole |
PO 600 mg twice a day (or IV 500 mg every twelve hours if GI absorption is compromised or patient is nil by mouth) |
Severe penicillin allergy
Start the following and consult Infectious Diseases/Clinical Microbiology:
clindamycin |
IV 600 mg every eight hours |
AND EITHER
gentamicin |
OR
ciprofloxacin |
IV 400 mg every twelve hours |
See Community-acquired Pneumonia, pathogens known.
Topic Code: 557687